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Product   Name :

Gelsolin

Cat No. :

CSP0032

Uniprot   ID：

P06396

Gene Description：

Gelsolin   (amyloidosis, Finnish type)

Synonyms：

Actin depolymerizing factor, ADF, AGEL, Brevin, GSN

Species：

Human

Source：

E.coli, Recombinant

Character：

Liquid

Application   :

Immunogen;   Standard; Calibrator

Concentration：

1mg/ml

Purity：

>90%

QA   Standard：

SDS PAGE

Buffer:

0.15M PBS, pH 7.5 with 50% glycerol

Storage:

-20℃ for one year

Background：

Gelsolin (GSN) is an actin binding protein that   regulates actin-severing/depolymerizing in a calcium dependent manner, and   acts as a multifunctional regulator for cell metabolism and survival.   Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and   a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased   levels of pGSN are strongly associated with human diseases, such as, acute   liver injury, major trauma, myocardial infarction, inflammation, lung injury,   rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.