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  • 產(chǎn)品名稱(chēng)： Sibiromycin
  • 產(chǎn)品貨號： CS00007
  • 貨期： 現貨
  • 價(jià)格與訂購： 3000
  • 數量：
    庫存： 10
  • 規格： 1mg
  • 產(chǎn)品信息
  • 如何訂購
    產(chǎn)品描述
    A naturally produced glycosylated pyrrolobenzodiazepines
    生物活性
    Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine[1][2]. 
    體外研究(In Vitro)
    Pyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity[1].
    Alkylation of DNA by anthramycin, sibiromycin and tomaymycin is sequence specific with the following trend for binding preference 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py[1].
    Sibiromycin shows cytotoxicity against L1210 (leukemia), ADJ/PC6 (plasmacytoma) and CH1 (ovarian) cells with IC50s of ranging 0.000017 ~0.0029 μM[1].
    (We have not independently confirmed the accuracy of these methods. They are for reference only.)
    別名
    西伯利亞霉素 
    純度
    95%
    分子量
    475.53 
    分子式
    C24H33N3O7
    CAS No.
    12684-33-2
    運輸條件
    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Please store the product under the recommended conditions in the Certificate of Analysis.
    參考文獻
    [1]. Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293.
    [2]. Li W, et al. Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol. 2009;75(9):2869-2878.
    Note
    For research use only .