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  • 產(chǎn)品名稱(chēng)： DM4
  • 產(chǎn)品貨號： CS00038
  • 貨期： 現貨
  • 價(jià)格與訂購： 1500
  • 數量：
    庫存： 10
  • 規格： 10mg
  • 產(chǎn)品信息
  • 如何訂購
    產(chǎn)品描述
     DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. 
    靶點(diǎn)活性
    Others 
    體外活性
    DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. 
    別名
    美登素 DM4 , Ravtansine
    純度
    98%
    分子量
    780.37 
    分子式
    C38H54ClN3O10S 
    CAS No.
    796073-69-3 
    存儲
    Powder: -20°C for 3 years
    In solvent: -80°C for 2 years
    溶解度
    DMSO: 99 mg/mL (126.86 mM), Need ultrasonic
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    參考文獻
    1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
    Note
    For research use only .