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  • 產(chǎn)品名稱(chēng)： DXD
  • 產(chǎn)品貨號： CS00056
  • 貨期： 現貨
  • 價(jià)格與訂購： 1390
  • 數量：
    庫存： 10
  • 規格： 1mg
  • 產(chǎn)品信息
  • 如何訂購
    產(chǎn)品描述
     Dxd is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. 
    靶點(diǎn)活性
    Topoisomerase I    Camptothecins  
    體外活性
    Dxd shows obviously suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines with IC50s of 26.8, 25.4, and 6.7 ng/mL respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL)[1]. 
    體內活性
    Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM. In HER2 low-expressing ST565 and ST313 models has HER2 IHC 1+/FISH-negative expression[1].
    別名
    Exatecan derivative for ADC , 化合物Dxd
    純度
    98%
    分子量
    493.48 
    分子式
    C26H24FN3O6
    CAS No. 
    1599440-33-1
    存儲
    Powder: -20°C for 3 years
    In solvent: -80°C for 2 years
    溶解度
    DMSO: 50 mg/mL (101.32 mM)
    H2O: insoluble
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    參考文獻
    1. Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.
    Note
    For research use only .