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  • 產(chǎn)品名稱(chēng)： Compound 401
  • 產(chǎn)品貨號： CS3586
  • 貨期： 現貨
  • 價(jià)格與訂購： 600
  • 數量：
    庫存： 100
  • 規格： 2mg 5mg 10mg
  • 產(chǎn)品信息
  • 如何訂購
    產(chǎn)品描述
    Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
    靶點(diǎn)活性
    DNA-PK
    體外活性
    Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).
    別名
    2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one
    純度
    99.76%
    分子量
    281.31
    分子式
    C16N15H3O2
    CAS No
    168425-64-7
    存儲
    0-4℃ for short term (days to weeks), or -20℃ for long term (months).
    溶解度
    DMSO: 6 mg/mL
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    icon
    Note
    For research use only .